Biologist - NIH - Rockville, MD
Kelly Government Solutions is a strategic supplier and business partner to the federal government and its key suppliers. Through our partnership with the National Institutes of Health, Kelly Government Solutions offers administrative, IT, engineering, scientific, and healthcare professionals the opportunity to work with one of the most prestigious research organizations in the world. We are currently seeking a Biologist to work onsite with the National Institutes of Health in Rockville, MD.
OVERVIEW. This is a long-term, open-ended contract position which offers:
- Competitive salary with a comprehensive benefits package.
- Tremendous room for personal growth and career development.
- Opportunity to work at the National Institutes of Health (NIH), the world's foremost medical research center.
TASKS/SERVICES. The contractor shall:
- Function as a biologist for the assigned Therapeutic Development Branch (TDB) projects, including but not limited to:
- Function as a biologist for the Endosome CRADA project. This project is related to the drug discovery and development for endocytosis inhibitors related to opioid signaling among others
- Evaluate existing nanoparticle formulations of endosomal GPCR inhibitors.
- Perform the functional assays to support chemists' effort on lead optimization such as endosomal inhibitors or activators and drugs that phenotypically reduce endocytosis.
- Search and read literature references related to the project and develop assays to measure and to study the mechanism of receptor endocytosis and signaling
- Perform biological experiments to support preclinical development of the projects.
- Participant in weekly project meetings for the assigned projects.
- Present biological ideas/experimental results and participate/lead discussions in project meetings.
- Evaluate and apply new technologies and instruments to improve physiologically relevance of disease models in the lab:
- Establishment human induced pluripotent stem cell (iPSC)-derived neurons for disease modeling.
- Set up 3D brain organoids for disease modeling
- Characterization of human iPSC-derived neurons and brain organoids including developmental analysis and disease phenotype study.
- Lead compound validation in human iPSC-derived neurons and 3D brain models.
- Assay development and assay optimization:
- Carry out assay development for the assigned TDB projects for library and cherry-pick compound screens.
- Optimize screening assays to improve screening throughput and assay reproducibility.
- Support medicinal chemists for chemical optimization of lead compounds:
- Perform compound screening assays to determine potency and efficacy of compounds synthesized by chemists.
- Analyze the results and report data to chemists.
- Carry out mechanistic studies such as drug target identification and characterization of compound reversibility and competitive/noncompetitive mechanism.
- Carry out drug repurposing screens:
- Work with assay providers for assay development and assay transfer to the TDB program.
- Perform assay optimization and miniaturization.
- Carry out high throughput screening with known drugs and bioactive compounds to identify active compounds.
- Confirm primary hits and perform secondary/tertiary assay to narrow down hit to 1 to 3 top lead compounds.
- Perform mechanistic study to characterize the top lead compounds.
- Direct communication with collaborators and project teams.
- Presentation and publication:
- Maintain good recodes and communication with collaborators.
- Present results in both internal and external scientific meetings.
- Write and submit scientific manuscripts. Publish 1-2 papers per year
- Assist the previous postdoctoral fellows for the manuscript's revision
- Engage in broad collaborations with other members in the group.
- Work closely with other staff scientists, postdoctoral fellows and IRTA fellows in the group.
REQUIREMENTS. The contractor must have:
- Ph.D. degree in a science related field; three (3) years of specialized experience plus a Master's degree is equivalent to a Ph.D.; five (5) years of specialized experience plus a Bachelor's degree is equivalent to a Ph.D.
- Minimum of two (2) years of related experience.
- Experience in assay development, imaging analysis, compound screening, lead identification.
- Experience in in vitro and in vivo disease model systems.
- Ability to multitask and pay close attention to experiment details.
- Experience with Microsoft Office Suite (MS Word, Excel, Outlook, PowerPoint) and Prism graphic program.
- Ability to maintain accurate and detailed records of laboratory experiments.
- Capable of writing scientific manuscripts for publication.
- Strong communications skills, both oral and written.
- Excellent analytical, organizational and time management skills.
PLEASE APPLY ONLINE.
Note that the phone number for our NIH branch is not listed. Due to the high volume of inquiries, we regret that we cannot accept phone calls. All qualified candidates will be contacted.
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